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KMID : 1059520130570060738
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Journal of the Korean Chemical Society
2013 Volume.57 No. 6 p.738 ~ p.743
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Synthesis of Glucuronic Acid Conjugates of Linoleic Acid Metabolites
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Kang Dong-Wook
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Abstract
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Linoleic acid and its metabolites have various medicinal effects with carboxylic acid functional group. General carboxylic acid compounds are discovered as glucuronide metabolites by UGT glucuronosyl transferase at liver. Consequently, glucuronides of linoleic acid metabolites are expected as potent conjugated metabolite. A previous study reported two epoxide metabolites and two dihydroxy metabolites of linoleic acid. There are prepared their glucuronic acid conjugated compounds as potent linoleic acid metabolites.
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KEYWORD
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Conjugate, Epoxidation, Glucuronic acid, Linoleic acid,, Metabolite
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